OPRA Question Bank: 2,524 Practice Questions with Worked Explanations

What you get

• 2,524 clinically-reviewed questions across all five OPRA domains — none of them recalled or reproduced exam material
• Option-by-option reasoning on every question, so you learn why each distractor is wrong rather than just which letter was right
• A core concept and a memory hook on every item, plus a cited Australian source — Therapeutic Guidelines, the AMH or the TGA — on 100% of questions
• Three difficulty tiers (Easy, Moderate, OPRA Level) so you can build up rather than being thrown in at exam standard
• Full-length timed mock exams — 120 questions in 150 minutes, sampled to approximately match the domain weightings published in the APC OPRA Exam Guide
• Spaced repetition, per-topic performance tracking and a readiness gauge against ClinicalStem's own 70% practice benchmark

Built for the Australian exam

ClinicalStem was built around the OPRA content areas published in the APC's own Exam Guide and against current Australian clinical references. Questions are original practice material, not recalled or reproduced examination content, and every item is mapped to an OPRA domain and supported by a cited Australian reference. Questions and explanations are reviewed for clinical accuracy against current Australian references before publication.

• 2,524 questions
• 5 OPRA content areas
• 100% source-cited
• 120 questions per full mock

Questions by domain

The bank broadly follows the exam's published weighting rather than splitting evenly across domains. Therapeutics and patient care is the largest content area in the APC's OPRA Exam Guide at around 45%, and it is the largest here too. See the full syllabus breakdown for what each domain covers.

• Therapeutics and patient care — 1,122 questions
• Biomedical sciences — 439 questions
• Pharmacology and toxicology — 380 questions
• Pharmacokinetics and pharmacodynamics — 302 questions
• Medicinal chemistry and biopharmaceutics — 281 questions

Questions by therapeutic area

Within Therapeutics, questions are tagged to 36 topics so you can drill a specific weakness rather than working through a shuffled pile. Cardiovascular, medication safety, infectious diseases, endocrine, respiratory, women's health, neurology, mental health, oncology and paediatrics all have dedicated sets.

Many of these topics also have a free written guide behind them, so you can read the concept and then test it: Hypertension · Type 2 diabetes · Warfarin and anticoagulation · Asthma and COPD · Antimicrobial selection · Heart failure · Thyroid disorders · Antidepressants

Practising by difficulty

Every question carries a difficulty tier reflecting ClinicalStem's own methodology, not an official APC classification — the tiers correlate with the kind of thinking required rather than being an arbitrary label. Easy items lean toward recall, Moderate toward understanding, and OPRA Level toward application in a clinical scenario. Filtering by tier lets you build confidence on a new topic before moving to exam-standard items on it, instead of bouncing off the hardest questions first.

Timed practice and mock exams

Untimed tutor mode shows the explanation as soon as you answer, which is how you learn. Timed mode withholds it until the end, which is how you rehearse. When you're ready for the real thing, a full mock exam runs 120 questions in 150 minutes — about 75 seconds a question — sampled to approximately match the domain weightings published in the APC OPRA Exam Guide, and scored with a per-domain breakdown.

Explanations that teach, not just mark

An answer key tells you that you were wrong. A worked explanation tells you why the option you picked was tempting, and what the question was actually testing.

Every question here carries reasoning for each of the four options, a core concept that generalises beyond the specific item, a memory hook, and a source reference — so if an explanation contradicts what you were taught elsewhere, you can go and check the cited Australian reference rather than taking our word for it. That matters more for overseas-trained candidates than almost anything else, because familiar medicines, guidelines and clinical practices may differ from those used in Australia — and a citation lets you check which is which rather than take either version on trust.

Tracking what to study next

Answering questions is the easy part; knowing what to do next is where most preparation breaks down. The bank records per-topic accuracy, resurfaces questions you got wrong using spaced-repetition intervals designed to reinforce them before they fade, and reports a readiness estimate against ClinicalStem's own 70% practice benchmark, broken down by domain and weighted by how much of each domain you've actually attempted.

It also tracks confidence separately from correctness — the questions you got right while unsure, and the ones you got wrong while certain. The second group is the dangerous one, and it is invisible in a plain score.

Try it before creating an account

You can answer a sample question and work through the entire Calculations Lab without signing up at all, and read all of the free study guides the same way. A free account adds 50 questions (10 per domain), 5 Crash Course modules and progress tracking, with no payment details required.